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Orforglipron produced a significantly higher NTS-to-AP ratio, reflecting a bias towards NTS-dominant engagement, whereas danuglipron and liraglutide yielded lower ratios that aligned with a more AP-skewed, nausea-like activation profile, in keeping with their distinct pharmacokinetic and signalling properties 7,8,9 (Fig
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Motor nerve excitability was assessed by the function of voltage-gated sodium and potassium ion channels and sodium-potassium pumps
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